Bibliography of Pragmatics Online: 12th Release, updated and expanded

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Calcium and Vitamin D Supplementation in Men

Calcium and vitamin D supplements reverse secondary hyperparathyroidism and are widely prescribed to prevent osteoporotic fractures, with proven antifracture efficacy when targeted to individuals with documented insufficiencies. Men who should particularly be considered for calcium and vitamin D supplements include elderly or institutionalized individuals, patients with documented osteoporosis on antiresorptive or anabolic medication, and individuals receiving glucocorticoids. Benefits are most apparent when a daily dose of 1000–1200 mg calcium is complemented with 800 IU vitamin D. Compliance is the key to optimizing clinical efficacy. While (conventionally dosed) vitamin D has not been associated with safety concerns, recent meta-analytic data have provided evidence to suggest that calcium supplements (without coadministered vitamin D) may potentially be associated with cardiovascular risks

Accident Investigation and Learning to Improve Safety Management in Complex System: Remaining Challenges: Proceedings of the 55th ESReDA Seminar

Accident investigation and learning from events are fundamental processes in safety management, involving technical, human, organisational and societal dimensions. The European Safety, Reliability and Data Association, ESReDA, has a long tradition in gathering together experts in the field to work together, and to share and explore experiences of using various paradigms, approaches, methods databased and implementation of safety systems across different industries. The 55th ESReDA seminar on “Accident Investigation and Learning to Improve Safety Management in Complex System: Remaining Challenges” attracted more than 80 participants from industry, authorities, operators, research centres and academia. The seminar programme consisted of 22 technical papers, three keynote speeches and a workshop to debate about the remaining challenges of accident investigation and potential innovative breakthroughs.JRC.G.10-Knowledge for Nuclear Security and Safet

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis

Acknowledgments This work was supported by European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) (Fungi in the setting of inflammation, allergy and autoimmune diseases: Translating basic science into clinical practices ‘‘ALLFUN’’) to D.C.I., F.C., C.F., M.G.N., and N.A.R.G. M.G.N and J.Q. were supported by a Vici grant of The Netherlands Organization of Scientific Research (to M.G.N.). M.G.N. was supported by an ERC Consolidator Grant (nr. 310372). N.A.R.G. was also supported by the Wellcome Trust (086827, 075470, 097377, & 101873).Peer reviewedPublisher PD

The multiple-specificity landscape of modular peptide recognition domains

Using large scale experimental datasets, the authors show how modular protein interaction domains such as PDZ, SH3 or WW domains, frequently display unexpected multiple binding specificity. The observed multiple specificity leads to new structural insights and accurately predicts new protein interactions

Vestibular Infant Screening (VIS)–Flanders : results after 1.5 years of vestibular screening in hearing-impaired children

Due to the close anatomical relationship between the auditory and vestibular end organs, hearing-impaired children have a higher risk for vestibular dysfunction, which can affect their (motor) development. Unfortunately, vestibular dysfunction often goes unnoticed, as vestibular assessment in these children is not standard of care nowadays. To timely detect vestibular dysfunction, the Vestibular Infant Screening–Flanders (VIS–Flanders) project has implemented a basic vestibular screening test for hearing-impaired infants in Flanders (Belgium) with a participation rate of 86.7% during the first year and a half. The cervical Vestibular Evoked Myogenic Potentials (cVEMP) test was applied as vestibular screening tool to map the occurrence of vestibular (mainly saccular) dysfunction in this population. At the age of 6 months, 184 infants were screened. No refers on vestibular screening were observed in infants with permanent conductive hearing loss. In infants with permanent sensorineural hearing loss, a cVEMP refer rate of 9.5% was observed. Failure was significantly more common in infants with severe-profound compared to those with mild-moderate sensorineural hearing loss (risk ratio = 9.8). Since this is the first regional study with a large sample size and successful participation rate, the VIS–Flanders project aims to set an example for other regions worldwide